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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Treatment with non-steroidal anti-inflammatory drugs in patients after myocardial infarction - a systematic review

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  1. The efficacy and safety of exenatide once weekly in patients with type 2 diabetes

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  2. Non-insulin pharmacological therapies for treating type 1 diabetes

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  3. Exenatide: pharmacokinetics, clinical use, and future directions

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  4. Management of cardiovascular disease in patients with psoriasis

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  1. Time in therapeutic range and risk of thromboembolism and bleeding in patients with a mechanical heart valve prosthesis

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  2. Socioeconomic position and one-year mortality risk among patients with heart failure: A nationwide register-based cohort study

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  3. Incidence of heart failure after pacemaker implantation: a nationwide Danish Registry-based follow-up study

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  4. Incidence of atrial fibrillation in different major cancer subtypes: a Nationwide population-based 12 year follow up study

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  5. Long-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Left-Sided Heart Valve Surgery

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INTRODUCTION: Studies over the past decade have shown that NSAIDs are associated with increased cardiovascular risk and may predispose to myocardial infarction in healthy individuals. Despite this knowledge patients with established cardiovascular disease are frequently treated with NSAIDs. The benefits versus potential harm of treatment need careful assessment.

AREAS COVERED: Observational studies and clinical trials providing information about outcome of NSAID treatment in post MI patients were retrieved; fourteen articles in total: two case-control studies, two randomized double-blind trials and ten cohort studies. The studies had a follow-up time between 30 days and 15 years. Two studies reported of risk of atrial fibrillation, and only one addressed antithrombotic treatment.

EXPERT OPINION: The risk of death and reinfarction in this group of patients is well established. Further studies are needed to investigate factors increasing the risk of atrial fibrillation. The correlation between recommended pharmaceutical treatment post MI and NSAIDs needs to be further examined. None of the studies examined correlated their results to dosages available over the counter.

Original languageEnglish
JournalExpert Opinion on Pharmacotherapy
Volume17
Issue number10
Pages (from-to)1387-94
Number of pages8
ISSN1465-6566
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Journal Article

ID: 48304937