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Treatment with Fenofibrate to a Patient with Newly Diagnosed Type 1 Diabetes, Rendering Him Insulin Independent

Rand F Al-Chalabi*, Karsten Stig Buschard, Frans Brandt

*Corresponding author for this work

Abstract

A 61-year-old man was diagnosed with late-onset Type 1 Diabetes in 2018, with strong positive GAD-65, subnormal
C-peptide and highly elevated HbA1C. The patient presented with symptoms of polyuria, polydipsia and fatigue. Before admission
to the hospital, the patient had, started treatment with metformin, and this treatment was continued under close observation and
follow-up. Fenofibrate was prescribed at four months post-diagnosis. Follow-up showed an increased C-peptide of 150% and
a decrease in GAD-65 to 50 IU\L. At the 4-year follow-up, the patient still produces his own insulin, is well-regulated and has
no complications. He has never needed treatment with insulin. In conclusion, a 61-year-old man with newly diagnosed Type 1
Diabetes started up with metformin and later fenofibrate, has, after 5 years not yet developed a need for insulin.
Original languageEnglish
Article number101799
JournalAnnals of Case Reports
Volume9
Issue number3
ISSN2574-7754
DOIs
Publication statusPublished - 2025

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