Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study

Mette Brandt-Christensen; Kajsa Kvist; Flemming Mørkeberg Nilsson; Per Kragh Andersen; Lars Vedel Kessing

doi:10.1002/mds.21472

Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study

Mette Brandt-Christensen, Kajsa Kvist, Flemming Mørkeberg Nilsson, Per Kragh Andersen, Lars Vedel Kessing

10 Citations (Scopus)

Abstract

Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04-2.16)) and with persons who got anti-diabetic drugs [RR: 1.58 (95% CI: 1.51-1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population-based studies of an association between PD and depression.

Original language	English
Journal	Movement disorders : official journal of the Movement Disorder Society
Volume	22
Issue number	14
Pages (from-to)	2037-42
Number of pages	6
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.21472
Publication status	Published - 31 Oct 2007

Keywords

Adult
Age Factors
Aged
Aged, 80 and over
Antidepressive Agents
Antiparkinson Agents
Confidence Intervals
Denmark
Depressive Disorder
Epidemiologic Studies
Female
Humans
Longitudinal Studies
Male
Middle Aged
Parkinson Disease
Pharmacoepidemiology
Registries
Retrospective Studies
Sex Factors
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1002/mds.21472

Cite this

Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study. / Brandt-Christensen, Mette; Kvist, Kajsa; Nilsson, Flemming Mørkeberg et al.
In: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, No. 14, 31.10.2007, p. 2037-42.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{34e0d8cd20d24061b9b38e9e5c4cf0e5,

title = "Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study",

abstract = "Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04-2.16)) and with persons who got anti-diabetic drugs [RR: 1.58 (95% CI: 1.51-1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population-based studies of an association between PD and depression.",

keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Antidepressive Agents, Antiparkinson Agents, Confidence Intervals, Denmark, Depressive Disorder, Epidemiologic Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Pharmacoepidemiology, Registries, Retrospective Studies, Sex Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Mette Brandt-Christensen and Kajsa Kvist and Nilsson, {Flemming M{\o}rkeberg} and Andersen, {Per Kragh} and Kessing, {Lars Vedel}",

year = "2007",

month = oct,

day = "31",

doi = "10.1002/mds.21472",

language = "English",

volume = "22",

pages = "2037--42",

journal = "Movement disorders : official journal of the Movement Disorder Society",

issn = "0885-3185",

publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",

number = "14",

}

TY - JOUR

T1 - Treatment with antiparkinson and antidepressant drugs

T2 - a register-based, pharmaco-epidemiological study

AU - Brandt-Christensen, Mette

AU - Kvist, Kajsa

AU - Nilsson, Flemming Mørkeberg

AU - Andersen, Per Kragh

AU - Kessing, Lars Vedel

PY - 2007/10/31

Y1 - 2007/10/31

N2 - Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04-2.16)) and with persons who got anti-diabetic drugs [RR: 1.58 (95% CI: 1.51-1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population-based studies of an association between PD and depression.

AB - Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04-2.16)) and with persons who got anti-diabetic drugs [RR: 1.58 (95% CI: 1.51-1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population-based studies of an association between PD and depression.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Antidepressive Agents

KW - Antiparkinson Agents

KW - Confidence Intervals

KW - Denmark

KW - Depressive Disorder

KW - Epidemiologic Studies

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Pharmacoepidemiology

KW - Registries

KW - Retrospective Studies

KW - Sex Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mds.21472

DO - 10.1002/mds.21472

M3 - Journal article

C2 - 17853463

SN - 0885-3185

VL - 22

SP - 2037

EP - 2042

JO - Movement disorders : official journal of the Movement Disorder Society

JF - Movement disorders : official journal of the Movement Disorder Society

IS - 14

ER -

Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study

Abstract

Keywords

Access to Document

Fingerprint

Cite this