Abstract
OBJECTIVE: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).
METHODS: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.
RESULTS: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.
CONCLUSION: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson's disease.
| Original language | English |
|---|---|
| Journal | Journal of neurology, neurosurgery, and psychiatry |
| Volume | 77 |
| Issue number | 6 |
| Pages (from-to) | 781-3 |
| Number of pages | 3 |
| ISSN | 0022-3050 |
| DOIs | |
| Publication status | Published - Jun 2006 |
Keywords
- Antidepressive Agents
- Antimanic Agents
- Antiparkinson Agents
- Anxiety Disorders
- Case-Control Studies
- Denmark
- Drug Prescriptions
- Epidemiologic Studies
- Female
- Humans
- Lithium Carbonate
- Male
- Mood Disorders
- Parkinson Disease
- Pharmacoepidemiology
- Risk Factors
- Journal Article