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Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

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@article{b6152d9db1d6474f8961556392651fcf,
title = "Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood",
abstract = "Relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia is a fatal event in the majority of cases. Immunotherapy may prevent an impending relapse if instituted at first molecular evidence of disease recurrence. Wilms tumor gene 1 (WT1) is overexpressed in the majority of children and may constitute a useful molecular marker of measurable residual disease applicable for disease monitoring in peripheral blood where the background amplification from healthy hematopoiesis is less prevalent compared with bone marrow. We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression.",
keywords = "Biological Monitoring/methods, Child, Hematopoietic Stem Cell Transplantation/methods, Humans, Immunosuppression/methods, Leukemia, Myeloid, Acute/genetics, Mutation, Neoplasm, Residual/diagnosis, Recurrence, Tandem Repeat Sequences, Time Factors, WT1 Proteins/blood, fms-Like Tyrosine Kinase 3/genetics",
author = "{L{\o}vvik Juul-Dam}, Kristian and Marianne Ifversen and {Guldborg Nyvold}, Charlotte and Maria Hansen and Henrik Hasle",
year = "2019",
doi = "10.1097/MPH.0000000000001365",
language = "English",
volume = "41",
pages = "417--419",
journal = "Journal of Pediatric Hematology / Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

AU - Løvvik Juul-Dam, Kristian

AU - Ifversen, Marianne

AU - Guldborg Nyvold, Charlotte

AU - Hansen, Maria

AU - Hasle, Henrik

PY - 2019

Y1 - 2019

N2 - Relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia is a fatal event in the majority of cases. Immunotherapy may prevent an impending relapse if instituted at first molecular evidence of disease recurrence. Wilms tumor gene 1 (WT1) is overexpressed in the majority of children and may constitute a useful molecular marker of measurable residual disease applicable for disease monitoring in peripheral blood where the background amplification from healthy hematopoiesis is less prevalent compared with bone marrow. We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression.

AB - Relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia is a fatal event in the majority of cases. Immunotherapy may prevent an impending relapse if instituted at first molecular evidence of disease recurrence. Wilms tumor gene 1 (WT1) is overexpressed in the majority of children and may constitute a useful molecular marker of measurable residual disease applicable for disease monitoring in peripheral blood where the background amplification from healthy hematopoiesis is less prevalent compared with bone marrow. We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression.

KW - Biological Monitoring/methods

KW - Child

KW - Hematopoietic Stem Cell Transplantation/methods

KW - Humans

KW - Immunosuppression/methods

KW - Leukemia, Myeloid, Acute/genetics

KW - Mutation

KW - Neoplasm, Residual/diagnosis

KW - Recurrence

KW - Tandem Repeat Sequences

KW - Time Factors

KW - WT1 Proteins/blood

KW - fms-Like Tyrosine Kinase 3/genetics

U2 - 10.1097/MPH.0000000000001365

DO - 10.1097/MPH.0000000000001365

M3 - Journal article

C2 - 31238330

VL - 41

SP - 417

EP - 419

JO - Journal of Pediatric Hematology / Oncology

JF - Journal of Pediatric Hematology / Oncology

SN - 1077-4114

IS - 5

ER -

ID: 58993059