Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Improved Survival of Children, Adolescents, and Young Adults With Head and Neck Soft Tissue Sarcomas in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Liposomal Cytarabine Induces Less Neurocognitive Dysfunction Than Intrathecal Methotrexate in an Animal Model

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Hepatotoxicity During Maintenance Therapy and Prognosis in Children With Acute Lymphoblastic Leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Declining mortality rates in children admitted to ICU following HCT

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Correction: ABO incompatibile graft management in pediatric transplantation

    Research output: Contribution to journalComment/debateResearchpeer-review

  • Kristian Løvvik Juul-Dam
  • Marianne Ifversen
  • Charlotte Guldborg Nyvold
  • Maria Hansen
  • Henrik Hasle
View graph of relations

Relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia is a fatal event in the majority of cases. Immunotherapy may prevent an impending relapse if instituted at first molecular evidence of disease recurrence. Wilms tumor gene 1 (WT1) is overexpressed in the majority of children and may constitute a useful molecular marker of measurable residual disease applicable for disease monitoring in peripheral blood where the background amplification from healthy hematopoiesis is less prevalent compared with bone marrow. We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
Volume41
Issue number5
Pages (from-to)417-419
Number of pages3
ISSN1077-4114
DOIs
Publication statusPublished - 2019

    Research areas

  • Biological Monitoring/methods, Child, Hematopoietic Stem Cell Transplantation/methods, Humans, Immunosuppression/methods, Leukemia, Myeloid, Acute/genetics, Mutation, Neoplasm, Residual/diagnosis, Recurrence, Tandem Repeat Sequences, Time Factors, WT1 Proteins/blood, fms-Like Tyrosine Kinase 3/genetics

ID: 58993059