Treatment of anemia with darbepoetin alfa in systolic heart failure

Karl Swedberg; James B Young; Inder S Anand; Sunfa Cheng; Akshay S Desai; Rafael Diaz; Aldo P Maggioni; John J V McMurray; Christopher O'Connor; Marc A Pfeffer; Scott D Solomon; Hong Yan Sun; Michal Tendera; Dirk J van Veldhuisen; RED-HF Committees; Jens Erik Rokkedal Nielsen

doi:10.1056/NEJMoa1214865

Treatment of anemia with darbepoetin alfa in systolic heart failure

Karl Swedberg, James B Young, Inder S Anand, Sunfa Cheng, Akshay S Desai, Rafael Diaz, Aldo P Maggioni, John J V McMurray, Christopher O'Connor, Marc A Pfeffer, Scott D Solomon, Hong Yan Sun, Michal Tendera, Dirk J van Veldhuisen, RED-HF Committees, Jens Erik Rokkedal Nielsen

Department of Medicine, Glostrup

508 Citations (Scopus)

Abstract

Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.

Original language	English
Journal	The New England journal of medicine
Volume	368
Issue number	13
Pages (from-to)	1210-9
Number of pages	10
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1214865
Publication status	Published - 28 Mar 2013

Keywords

Aged
Anemia
Double-Blind Method
Erythropoietin
Female
Heart Failure, Systolic
Hematinics
Hemoglobins
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Proportional Hazards Models
Shock, Septic
Stroke
Thromboembolism
Treatment Failure

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10.1056/NEJMoa1214865

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Swedberg, K., Young, J. B., Anand, I. S., Cheng, S., Desai, A. S., Diaz, R., Maggioni, A. P., McMurray, J. J. V., O'Connor, C., Pfeffer, M. A., Solomon, S. D., Sun, H. Y., Tendera, M., van Veldhuisen, D. J., RED-HF Committees, & Nielsen, J. E. R. (2013). Treatment of anemia with darbepoetin alfa in systolic heart failure. The New England journal of medicine, 368(13), 1210-9. https://doi.org/10.1056/NEJMoa1214865

Swedberg, K, Young, JB, Anand, IS, Cheng, S, Desai, AS, Diaz, R, Maggioni, AP, McMurray, JJV, O'Connor, C, Pfeffer, MA, Solomon, SD, Sun, HY, Tendera, M, van Veldhuisen, DJ, RED-HF Committees & Nielsen, JER 2013, 'Treatment of anemia with darbepoetin alfa in systolic heart failure', The New England journal of medicine, vol. 368, no. 13, pp. 1210-9. https://doi.org/10.1056/NEJMoa1214865

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abstract = "Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.",

keywords = "Aged, Anemia, Double-Blind Method, Erythropoietin, Female, Heart Failure, Systolic, Hematinics, Hemoglobins, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Shock, Septic, Stroke, Thromboembolism, Treatment Failure",

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AU - Swedberg, Karl

AU - Young, James B

AU - Anand, Inder S

AU - Cheng, Sunfa

AU - Desai, Akshay S

AU - Diaz, Rafael

AU - Maggioni, Aldo P

AU - McMurray, John J V

AU - O'Connor, Christopher

AU - Pfeffer, Marc A

AU - Solomon, Scott D

AU - Sun, Hong Yan

AU - Tendera, Michal

AU - van Veldhuisen, Dirk J

AU - RED-HF Committees

AU - Nielsen, Jens Erik Rokkedal

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N2 - Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.

AB - Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.

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KW - Anemia

KW - Double-Blind Method

KW - Erythropoietin

KW - Female

KW - Heart Failure, Systolic

KW - Hematinics

KW - Hemoglobins

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Shock, Septic

KW - Stroke

KW - Thromboembolism

KW - Treatment Failure

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DO - 10.1056/NEJMoa1214865

M3 - Journal article

C2 - 23473338

SN - 0028-4793

VL - 368

SP - 1210

EP - 1219

JO - The New England journal of medicine

JF - The New England journal of medicine

IS - 13

ER -

Treatment of anemia with darbepoetin alfa in systolic heart failure

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