Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)

Pär I Johansson; Louise Bochsen; Jakob Stensballe; Niels H Secher

doi:10.1016/j.transci.2008.05.012

Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)

Pär I Johansson, Louise Bochsen, Jakob Stensballe, Niels H Secher

Abstract

We investigated the effect of administering a transfusion package encompassing 5 red blood cells (RBC), 5 fresh frozen plasma (FFP), and 2 platelet concentrates (PC) on clot formation and stability as evaluated by Thrombelastograph (TEG) in 10 patients presenting with massive bleeding. Blood was obtained before and after administering the transfusion packages. Six patients were hypocoagulable before administration of the transfusion package, whereas none of the patients were hypocoagulable after transfusion of up to 7 transfusion packages (p=0.01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients.

Original language	English
Journal	Transfusion and Apheresis Science
Volume	39
Issue number	1
Pages (from-to)	3-8
Number of pages	6
ISSN	1473-0502
DOIs	https://doi.org/10.1016/j.transci.2008.05.012
Publication status	Published - Aug 2008

Keywords

Adolescent
Adult
Aged
Blood Coagulation
Blood Component Transfusion
Disease-Free Survival
Female
Hemorrhage/mortality
Humans
Male
Middle Aged
Thrombelastography/instrumentation

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10.1016/j.transci.2008.05.012

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title = "Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)",

abstract = "We investigated the effect of administering a transfusion package encompassing 5 red blood cells (RBC), 5 fresh frozen plasma (FFP), and 2 platelet concentrates (PC) on clot formation and stability as evaluated by Thrombelastograph (TEG) in 10 patients presenting with massive bleeding. Blood was obtained before and after administering the transfusion packages. Six patients were hypocoagulable before administration of the transfusion package, whereas none of the patients were hypocoagulable after transfusion of up to 7 transfusion packages (p=0.01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients.",

keywords = "Adolescent, Adult, Aged, Blood Coagulation, Blood Component Transfusion, Disease-Free Survival, Female, Hemorrhage/mortality, Humans, Male, Middle Aged, Thrombelastography/instrumentation",

author = "Johansson, {P{\"a}r I} and Louise Bochsen and Jakob Stensballe and Secher, {Niels H}",

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doi = "10.1016/j.transci.2008.05.012",

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T1 - Transfusion packages for massively bleeding patients

T2 - the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)

AU - Johansson, Pär I

AU - Bochsen, Louise

AU - Stensballe, Jakob

AU - Secher, Niels H

PY - 2008/8

Y1 - 2008/8

N2 - We investigated the effect of administering a transfusion package encompassing 5 red blood cells (RBC), 5 fresh frozen plasma (FFP), and 2 platelet concentrates (PC) on clot formation and stability as evaluated by Thrombelastograph (TEG) in 10 patients presenting with massive bleeding. Blood was obtained before and after administering the transfusion packages. Six patients were hypocoagulable before administration of the transfusion package, whereas none of the patients were hypocoagulable after transfusion of up to 7 transfusion packages (p=0.01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients.

AB - We investigated the effect of administering a transfusion package encompassing 5 red blood cells (RBC), 5 fresh frozen plasma (FFP), and 2 platelet concentrates (PC) on clot formation and stability as evaluated by Thrombelastograph (TEG) in 10 patients presenting with massive bleeding. Blood was obtained before and after administering the transfusion packages. Six patients were hypocoagulable before administration of the transfusion package, whereas none of the patients were hypocoagulable after transfusion of up to 7 transfusion packages (p=0.01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients.

KW - Adolescent

KW - Adult

KW - Aged

KW - Blood Coagulation

KW - Blood Component Transfusion

KW - Disease-Free Survival

KW - Female

KW - Hemorrhage/mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Thrombelastography/instrumentation

U2 - 10.1016/j.transci.2008.05.012

DO - 10.1016/j.transci.2008.05.012

M3 - Journal article

C2 - 18583193

SN - 1473-0502

VL - 39

SP - 3

EP - 8

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

IS - 1

ER -

Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)

Abstract

Keywords

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