Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Transcutaneous Vagus Nerve Stimulation in Patients With Severe Traumatic Brain Injury: A Feasibility Trial

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Reprogramming Sacral Neuromodulation for Sub-Optimal Outcomes: Evidence and Recommendations for Clinical Practice

    Research output: Contribution to journalReviewResearchpeer-review

  2. Sacral Neuromodulation: Standardized Electrode Placement Technique

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Stretch reflex regulation in healthy subjects and patients with spasticity

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Repetitive focal seizures evolving into ictal asystole: a case report with 18 seizures during video-EEG monitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comparing Seizure-Related Death and Suicide in Younger Adults with Epilepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Preclinical studies have shown that surgically implanted vagus nerve stimulation (VNS) promotes recovery of consciousness and cognitive function following experimental traumatic brain injury (TBI). The aim of this study is to report the feasibility and safety of a noninvasive transcutaneous vagus nerve stimulation (tVNS) in patients with persistent impairment of consciousness following severe TBI.

MATERIALS AND METHODS: The feasibility of tVNS was evaluated in five patients presenting with diffuse axonal injury and reduced dominant EEG activity one month following severe TBI. tVNS was applied to the left cymba conchae of the external ear using a skin electrode four hours daily for eight weeks. Possible effects of tVNS on physiological parameters and general side effects were recorded. In addition, we report the rate of recovery using coma recovery scale revised (CRS-R).

RESULTS: The tVNS regime of four hours daily for eight weeks was feasible and well tolerated with little side effects and no clinically relevant effects on physiological parameters. Three patients showed improvements (>3 points) in the CRS-R following eight weeks tVNS.

CONCLUSION: We demonstrated that tVNS is a feasible and safe VNS strategy for patients following severe TBI. Controlled studies are needed to clarify whether tVNS has a potential to promote recovery of consciousness following severe TBI.

Original languageEnglish
JournalNeuromodulation
Volume23
Issue number6
Pages (from-to)859-864
Number of pages6
ISSN1094-7159
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • feasibility study, Transcutaneous vagus nerve stimulation, traumatic brain injury, vagus nerve stimulation

ID: 59623879