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Transcerebral net exchange of vasoactive peptides and catecholamines during lipopolysaccharide-induced systemic inflammation in healthy humans

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The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a 4-hour intravenous LPS infusion (0.3 ng·kg-1) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety-Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP, and catecholamines by the Fick principle in 12 volunteers before and after LPS infusion. The cerebrovascular release of ET-1 was enhanced, whereas the transcerebral net exchange of CGRP and catecholamines was unaffected. Our findings thus point towards locally produced ET-1 within the cerebrovasculature as a contributor to cerebral vasoconstriction after LPS infusion.

Original languageEnglish
JournalCanadian Journal of Physiology and Pharmacology
Volume96
Issue number3
Pages (from-to)313-316
Number of pages4
ISSN0008-4212
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • Adult, Brain/blood supply, Calcitonin Gene-Related Peptide/metabolism, Catecholamines/metabolism, Endothelin-1/metabolism, Healthy Volunteers, Humans, Lipopolysaccharides/pharmacology, Male, Systemic Inflammatory Response Syndrome/metabolism, Vasoconstriction/drug effects

ID: 55495006