Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Bone mass density in lean and overweight women with polycystic ovary syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. On measurements of glucagon secretion in healthy, obese, and Roux-en-Y gastric bypass operated individuals using sandwich ELISA

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Managing patients on direct factor Xa inhibitors with rapid thrombelastography

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mobilising patients with severe acquired brain injury in intensive care (MAWERIC) - Protocol for a randomised cross-over trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostic criteria of CNS infection in patients with external ventricular drainage after traumatic brain injury: a pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reduced levels of pulmonary surfactant in COVID-19 ARDS

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Reliability of cerebral autoregulation using different measures of perfusion pressure in patients with subarachnoid hemorrhage

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Hypoxaemia is present in many critically ill patients, and may contribute to encephalopathy. Changes in the passage of large neutral amino acids (LNAAs) across the blood-brain barrier (BBB) with an increased cerebral influx of aromatic amino acids into the brain may concurrently be present and also contribute to encephalopathy, but it has not been established whether hypoxaemia per se may trigger such changes. We measured cerebral blood flow (CBF) in 11 healthy men using the Kety-Schmidt technique and obtained paired arterial and jugular-venous blood samples for the determination of LNAAs by high performance liquid chromatography at baseline and after 9 hours of poikilocapnic normobaric hypoxia (12% O2). Transcerebral net exchange was determined by the Fick principle, and transport of LNAAs across the BBB was determined mathematically. Hypoxia increased both the systemic and corresponding cerebral delivery of the aromatic amino acid phenylalanine, and the branched-chain amino acids leucine and isoleucine. Despite this, the transcerebral net exchange values and mathematically derived brain extracellular concentrations for all LNAAs were unaffected. In conclusion, the observed changes in circulating LNAAs triggered by hypoxaemia do not affect the transcerebral exchange kinetics of LNAAs to such an extent that their brain extracellular concentrations are affected.

Original languageEnglish
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume79
Issue number8
Pages (from-to)595-600
Number of pages6
ISSN0036-5513
DOIs
Publication statusPublished - 17 Nov 2019

    Research areas

  • (MeSH ID): Aromatic amino acids (D024322), blood-brain barrier (D001812), branched-chain amino acids (D000597), hypoxia (D000860), metabolism (D008660)

ID: 58652641