Harvard
Kato, N, Loh, M, Takeuchi, F, Verweij, N, Wang, X, Zhang, W, Kelly, TN, Saleheen, D, Lehne, B, Mateo Leach, I, Drong, AW, Abbott, J, Wahl, S, Tan, S-T, Scott, WR, Campanella, G, Chadeau-Hyam, M, Afzal, U
, Ahluwalia, TS, Bonder, MJ, Chen, P, Dehghan, A, Edwards, TL, Esko, T, Go, MJ, Harris, SE, Hartiala, J, Kasela, S, Kasturiratne, A, Khor, C-C, Kleber, ME, Li, H, Mok, ZY, Nakatochi, M, Sapari, NS, Saxena, R, Stewart, AFR, Stolk, L, Tabara, Y, Teh, AL, Wu, Y, Wu, J-Y, Zhang, Y, Aits, I
, Husemoen, LLN, Sparsø, T, Hansen, T, Jørgensen, T, Linneberg, A, Sørensen, TIA & BIOS-consortium 2015, '
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation'
Nature Genetics, vol. 47, no. 11, pp. 1282-93.
https://doi.org/10.1038/ng.3405APA
Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., ... BIOS-consortium (2015).
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Nature Genetics,
47(11), 1282-93.
https://doi.org/10.1038/ng.3405CBE
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, Drong AW, Abbott J, Wahl S, Tan S-T, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U
, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor C-C, Kleber ME, Li H, Mok ZY, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu J-Y, Zhang Y, Aits I
, Husemoen LLN, Sparsø T, Hansen T, Jørgensen T, Linneberg A, Sørensen TIA, BIOS-consortium. 2015.
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Nature Genetics. 47(11):1282-93.
https://doi.org/10.1038/ng.3405MLA
Vancouver
Author
Kato, Norihiro ; Loh, Marie ; Takeuchi, Fumihiko ; Verweij, Niek ; Wang, Xu ; Zhang, Weihua ; Kelly, Tanika N ; Saleheen, Danish ; Lehne, Benjamin ; Mateo Leach, Irene ; Drong, Alexander W ; Abbott, James ; Wahl, Simone ; Tan, Sian-Tsung ; Scott, William R ; Campanella, Gianluca ; Chadeau-Hyam, Marc ; Afzal, Uzma
; Ahluwalia, Tarunveer S ; Bonder, Marc Jan ; Chen, Peng ; Dehghan, Abbas ; Edwards, Todd L ; Esko, Tõnu ; Go, Min Jin ; Harris, Sarah E ; Hartiala, Jaana ; Kasela, Silva ; Kasturiratne, Anuradhani ; Khor, Chiea-Chuen ; Kleber, Marcus E ; Li, Huaixing ; Mok, Zuan Yu ; Nakatochi, Masahiro ; Sapari, Nur Sabrina ; Saxena, Richa ; Stewart, Alexandre F R ; Stolk, Lisette ; Tabara, Yasuharu ; Teh, Ai Ling ; Wu, Ying ; Wu, Jer-Yuarn ; Zhang, Yi ; Aits, Imke
; Husemoen, Lise L N ; Sparsø, Thomas ; Hansen, Torben ; Jørgensen, Torben ; Linneberg, Allan ; Sørensen, Thorkild I A ; BIOS-consortium. /
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. In:
Nature Genetics. 2015 ; Vol. 47, No. 11. pp. 1282-93.
Bibtex
@article{48b4fd4005324aceaa5759cabb34f32f,
title = "Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation",
abstract = "We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.",
author = "Norihiro Kato and Marie Loh and Fumihiko Takeuchi and Niek Verweij and Xu Wang and Weihua Zhang and Kelly, {Tanika N} and Danish Saleheen and Benjamin Lehne and {Mateo Leach}, Irene and Drong, {Alexander W} and James Abbott and Simone Wahl and Sian-Tsung Tan and Scott, {William R} and Gianluca Campanella and Marc Chadeau-Hyam and Uzma Afzal and Ahluwalia, {Tarunveer S} and Bonder, {Marc Jan} and Peng Chen and Abbas Dehghan and Edwards, {Todd L} and T{\~o}nu Esko and Go, {Min Jin} and Harris, {Sarah E} and Jaana Hartiala and Silva Kasela and Anuradhani Kasturiratne and Chiea-Chuen Khor and Kleber, {Marcus E} and Huaixing Li and Mok, {Zuan Yu} and Masahiro Nakatochi and Sapari, {Nur Sabrina} and Richa Saxena and Stewart, {Alexandre F R} and Lisette Stolk and Yasuharu Tabara and Teh, {Ai Ling} and Ying Wu and Jer-Yuarn Wu and Yi Zhang and Imke Aits and Husemoen, {Lise L N} and Thomas Spars{\o} and Torben Hansen and Torben J{\o}rgensen and Allan Linneberg and S{\o}rensen, {Thorkild I A} and BIOS-consortium",
year = "2015",
month = "11",
doi = "10.1038/ng.3405",
language = "English",
volume = "47",
pages = "1282--93",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}
RIS
TY - JOUR
T1 - Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
AU - Kato, Norihiro
AU - Loh, Marie
AU - Takeuchi, Fumihiko
AU - Verweij, Niek
AU - Wang, Xu
AU - Zhang, Weihua
AU - Kelly, Tanika N
AU - Saleheen, Danish
AU - Lehne, Benjamin
AU - Mateo Leach, Irene
AU - Drong, Alexander W
AU - Abbott, James
AU - Wahl, Simone
AU - Tan, Sian-Tsung
AU - Scott, William R
AU - Campanella, Gianluca
AU - Chadeau-Hyam, Marc
AU - Afzal, Uzma
AU - Ahluwalia, Tarunveer S
AU - Bonder, Marc Jan
AU - Chen, Peng
AU - Dehghan, Abbas
AU - Edwards, Todd L
AU - Esko, Tõnu
AU - Go, Min Jin
AU - Harris, Sarah E
AU - Hartiala, Jaana
AU - Kasela, Silva
AU - Kasturiratne, Anuradhani
AU - Khor, Chiea-Chuen
AU - Kleber, Marcus E
AU - Li, Huaixing
AU - Mok, Zuan Yu
AU - Nakatochi, Masahiro
AU - Sapari, Nur Sabrina
AU - Saxena, Richa
AU - Stewart, Alexandre F R
AU - Stolk, Lisette
AU - Tabara, Yasuharu
AU - Teh, Ai Ling
AU - Wu, Ying
AU - Wu, Jer-Yuarn
AU - Zhang, Yi
AU - Aits, Imke
AU - Husemoen, Lise L N
AU - Sparsø, Thomas
AU - Hansen, Torben
AU - Jørgensen, Torben
AU - Linneberg, Allan
AU - Sørensen, Thorkild I A
AU - BIOS-consortium
PY - 2015/11
Y1 - 2015/11
N2 - We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
AB - We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
U2 - 10.1038/ng.3405
DO - 10.1038/ng.3405
M3 - Journal article
VL - 47
SP - 1282
EP - 1293
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
