Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

Sofi da Cunha-Bang, Dea Siggaard Stenbæk, Klaus Holst, Cecilie Löe Licht, Peter Steen Jensen, Vibe Gedsø Frøkjær, Erik Lykke Mortensen, Gitte Moos Knudsen

31 Citations (Scopus)

Abstract

Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [18F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.
Original languageEnglish
JournalPsychiatry Research
Volume212
Issue number2
Pages (from-to)125-31
Number of pages7
ISSN0165-1781
DOIs
Publication statusPublished - 30 May 2013

Keywords

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aggression
  • Female
  • Fluorodeoxyglucose F18
  • Frontal Lobe
  • Hormones
  • Humans
  • Impulsive Behavior
  • Ketanserin
  • Male
  • Middle Aged
  • Personality
  • Personality Inventory
  • Positron-Emission Tomography
  • Receptor, Serotonin, 5-HT2A
  • Serotonin Antagonists
  • Statistics, Nonparametric
  • Young Adult

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