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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Toward liquid biopsies in cancer treatment: application of circulating tumor DNA

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  2. Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study

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  3. Plasma total cell-free DNA is a prognostic biomarker of overall survival in metastatic solid tumour patients

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  4. Outcome of an enhanced diagnostic pipeline for patients suspected of inherited thrombocytopenia

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  5. Prognostic molecular markers in pediatric liver disease - Are there any?

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Circulating tumor DNA (ctDNA) refers to the fraction of cell-free DNA in a patient's blood originating from tumor cells. Increased knowledge about tumor genomics, improvements in targeted therapies, and accompanying advances in DNA-sequencing technologies have increased the interest in using ctDNA as a minimally invasive tool in cancer diagnostics and treatment. Especially, early tumor detection including identification of minimal residual disease and stratification of adjuvant therapy are promising approaches. Also, ctDNA showed to be reliable in treatment monitoring and can be used to assess therapy resistance due to the broad variety of tumor subclones captured in ctDNA. Therefore, using ctDNA in the clinical setting has the potential to improve therapeutic outcomes. In the present review, we summarize the status of ctDNA in oncology with focus of being an alternative to tissue biopsies in early detection and treatment monitoring.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number5
Pages (from-to)329-336
Number of pages8
ISSN0903-4641
DOIs
Publication statusPublished - May 2019

    Research areas

  • Circulating Tumor DNA/blood, Humans, Liquid Biopsy/methods, Mutation, Neoplasm, Residual/diagnosis, Neoplasms/genetics

ID: 59000406