Tourettes syndrom - Genetik, neuroanatomi og neurotransmittere

Nanette M.M. Mol Debes; Liselotte Skov; Helle Hjalgrim

Tourettes syndrom - Genetik, neuroanatomi og neurotransmittere

Translated title of the contribution: Tourette syndrome - Genetics, neuroanatomy and neurotransmitters

Nanette M.M. Mol Debes, Liselotte Skov, Helle Hjalgrim

Department of Paediatrics

3 Citations (Scopus)

Abstract

The etiology and pathophysiology of Tourette syndrome (TS) have not yet been clarified. Despite inconsistencies in the literature, some conclusions can be drawn on genetics, neuroanatomy and neurotransmitters. The inheritance of TS is unknown; the etiology seems to be polygenic. The basal ganglia are probably smaller in patients with TS. A dysfunction in the dopaminergic pathway causes tics. ADHD results from a decreased concentration of dopamine and an increased concentration of noradrenaline. OCD is caused by a dysfunction in serotonin and probably dopamine.

Translated title of the contribution	Tourette syndrome - Genetics, neuroanatomy and neurotransmitters
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	170
Issue number	35
Pages (from-to)	2695-2700
Number of pages	6
ISSN	0041-5782
Publication status	Published - 25 Aug 2008

Cite this

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AU - Mol Debes, Nanette M.M.

AU - Skov, Liselotte

AU - Hjalgrim, Helle

PY - 2008/8/25

Y1 - 2008/8/25

N2 - The etiology and pathophysiology of Tourette syndrome (TS) have not yet been clarified. Despite inconsistencies in the literature, some conclusions can be drawn on genetics, neuroanatomy and neurotransmitters. The inheritance of TS is unknown; the etiology seems to be polygenic. The basal ganglia are probably smaller in patients with TS. A dysfunction in the dopaminergic pathway causes tics. ADHD results from a decreased concentration of dopamine and an increased concentration of noradrenaline. OCD is caused by a dysfunction in serotonin and probably dopamine.

AB - The etiology and pathophysiology of Tourette syndrome (TS) have not yet been clarified. Despite inconsistencies in the literature, some conclusions can be drawn on genetics, neuroanatomy and neurotransmitters. The inheritance of TS is unknown; the etiology seems to be polygenic. The basal ganglia are probably smaller in patients with TS. A dysfunction in the dopaminergic pathway causes tics. ADHD results from a decreased concentration of dopamine and an increased concentration of noradrenaline. OCD is caused by a dysfunction in serotonin and probably dopamine.

UR - https://www.scopus.com/pages/publications/51149121228

M3 - Tidsskriftartikel

C2 - 18761860

AN - SCOPUS:51149121228

SN - 0041-5782

VL - 170

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IS - 35

ER -

Tourettes syndrom - Genetik, neuroanatomi og neurotransmittere

Abstract

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