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Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation

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Solid organ transplantation (SOT) recipients receive immunosuppressive therapy to avoid rejection of the transplanted organ. Immunosuppressive therapy increases the risk of infections. However, no existing marker reliably reveals the status of the immune function in SOT recipients. Torque-Teno virus or Transfusion-transmitted virus (TTV) has gained attention as a possible endogenous marker of the immune function. TTV is a non-enveloped, circular single strand DNA virus, and it may be considered a part of the human virome. In a bidirectional relationship, the immune system detects TTV and TTV may also modulate the activity of immune system. These characteristics have made the virus a possible candidate indicator of immune function. In this systematic review, we describe the role and potential function of TTV viral load as an endogenous marker of the immune function and consequently the level of immune suppression in SOT recipients.

Original languageEnglish
JournalTransplantation reviews (Orlando, Fla.)
Volume33
Issue number3
Pages (from-to)137-144
Number of pages8
ISSN0955-470X
DOIs
Publication statusPublished - Jul 2019

ID: 57714837