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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Topological principles and developmental algorithms might refine diffusion tractography

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  1. Ex vivo diffusion-weighted MRI tractography of the Göttingen minipig limbic system

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  2. Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

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  3. The number of neurons in specific amygdala regions is associated with boldness in mink: a study in animal personality

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  1. No detectable effect on visual responses using functional MRI in a rodent model of α-synuclein expression

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  2. Cytosolic diffusivity and microscopic anisotropy of N-acetyl aspartate in human white matter with diffusion-weighted MRS at 7 T

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  3. In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents

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  • Giorgio M Innocenti
  • Tim B Dyrby
  • Gabriel Girard
  • Etienne St-Onge
  • Jean-Philippe Thiran
  • Alessandro Daducci
  • Maxime Descoteaux
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The identification and reconstruction of axonal pathways in the living brain or "ex-vivo" is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural-functional correlates. Unfortunately, the methods suffer from juvenile drawbacks. In this perspective paper we mention several computational and developmental principles, which might stimulate a new generation of algorithms and a discussion bridging the neuroimaging and neuroanatomy communities.

Original languageEnglish
JournalBrain structure & function
Volume224
Issue number1
Pages (from-to)1-8
Number of pages8
ISSN0177-5154
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • Axons, Brain development, Brain pathways, Diffusion MRI, Tractography, Predictive Value of Tests, Brain Mapping/methods, Humans, Neural Pathways/diagnostic imaging, Neurogenesis, Brain/diagnostic imaging, Algorithms, Animals, Neuroimaging/methods, Axons/physiology, Image Interpretation, Computer-Assisted/methods, Models, Neurological, Diffusion Tensor Imaging/methods

ID: 55375742