Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

To Bubble or Not? A Systematic Review of Bubble Continuous Positive Airway Pressure in Children in Low- and Middle-Income Countries

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Neonatal bloodstream infections in a pediatric hospital in Vietnam: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Self-reported immunity and opinions on vaccination of hospital personnel among paediatric healthcare workers in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Infectious diseases detected by screening after arrival to Denmark in internationally adopted children

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hospitalizations for infections by age and sex: register-based study of Danish children 1977-2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Latent tuberculosis infection among minor asylum seekers in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Bubble-continuous positive airway pressure (bCPAP) is a simple, low-cost ventilation therapy with the potential to lower morbidity and mortality in children in low- and middle-income countries (LMICs).

AIM: To examine (i) whether bCPAP is a safe and effective treatment for children in all age-groups presenting with respiratory distress from any cause, (ii) LMIC-implemented bCPAP devices including their technical specifications and costs and (iii) the setting and level of health care bCPAP has been implemented in.

METHOD: A systematic search was performed of Embase, PubMed and Web of Science. Inclusion criteria: bCPAP for children with respiratory distress in all age groups in LMICs. Database searches were performed up to 1 November 2018.

RESULTS: A total of 24 publications were eligible for the review. For neonates bCPAP was superior in improving survival and clinical progression compared with oxygen therapy and mechanical ventilation (MV). In two studies bCPAP was superior to low flow oxygen in reducing mortality in children 29 days to 13 months. Respiratory rate reductions were significant across all ages. Only three of six studies in children of all ages evaluated serious adverse events. In 12 studies comprising 1338 neonates treated with bCPAP, pneumothorax was reported 27 times. The majority of studies were carried out at tertiary hospitals in middle-income countries and 50% implemented the most expensive bCPAP-device.

CONCLUSION: In neonates and children below 13 months bCPAP is a safe treatment improving clinical outcomes and reducing the need for MV, without an increase in mortality. High-quality studies from non-tertiary settings in low-income countries are needed.

Original languageEnglish
JournalJournal of Tropical Pediatrics
Volume66
Issue number3
Pages (from-to)339-353
Number of pages15
ISSN0142-6338
DOIs
Publication statusPublished - 1 Jun 2020

    Research areas

  • child, continuous positive airway pressure, developing countries, newborn, respiratory distress syndrome

ID: 58927648