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Tissue to plasma capillary permeability of 131I-albumin in the perfused rabbit ear

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The tissue to plasma transfer of 131I-albumin was recorded in perfused rabbit ears (n = 6) following equilibration for 24 hr. 125I-fibrinogen served as the plasma marker, and was introduced intravenously 15 min before clamping. The ears were rollerpump perfused with isotonic diluted plasma at a constant rate of (mean +/- SD) 5.1 +/- 1.5 ml (min.100 g)-1. The mean extravascular albumin distribution volume was 12.4 +/- 1.1 ml.100 g-1, and the fibrinogen volume (plasma volume in tissue) was 3.1 +/- 0.4 ml.100 g-1 as determined from biopsies of the contralateral ear. The initial transfer of albumin was marked, and occurred at rates corresponding to a unidirectional clearance (Cl(0)) of 0.068 +/- 0.012 ml (min.100 g)-1. However, with a reduction of mean interstitial albumin tracer content of no more than 4%, net transport decreased to reach slowly declining levels 5 to 10 times lower within 10 min of continued perfusion. The decrease was considered due to rapid exhaustion of a small interstitial pool of tracer immediately adjacent to the exchange vessel membrane, followed by an increasingly retarded outwash from more distant areas. The results suggest a bimodal structural resistance to albumin movement: a relatively low resistance in the capillary membrane, and a considerable restriction to albumin transport located within the interstitial space.

Original languageEnglish
JournalMicrovascular Research
Volume41
Issue number2
Pages (from-to)141-8
Number of pages8
ISSN0026-2862
Publication statusPublished - Mar 1991

    Research areas

  • Animals, Biomarkers, Biopsy, Capillary Permeability, Capillary Resistance, Ear, Fibrinogen, Iodine Radioisotopes, Rabbits, Serum Albumin, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

ID: 51664498