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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Tissue inhibitor of metalloproteinases-1 as a biological marker 
in colorectal cancer: influence of smoking on plasma levels?

Research output: Contribution to journalJournal articleResearchpeer-review

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  3. Assessment of the biological variation of plasma tissue inhibitor of metalloproteinases-1

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Background: At present plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) is undergoing validation as a biological marker in colorectal cancer (CRC). The clinical implementation of plasma TIMP-1 in prognosis, prediction, screening and monitoring CRC requires robust information as to the influence of preanalytical factors, including inter- and intrapersonal biological variations. The aim of the present study was to evaluate the possible effects of smoking on the level of TIMP-1 in plasma from healthy subjects.Materials and methods: Forty-six never-smokers and 48 daily smokers participated in the 13-week study. Smokers were randomized into 3 groups of 16 subjects each: one group continued to smoke, a second group refrained from smoking and used a transdermal nicotine patch, and a third group refrained from smoking and used placebo patches. Plasma TIMP-1 levels were determined using ELISA.Results: No significant differences in TIMP-1 levels could be shown between the smoking group, the 2 different abstinent smoking groups and the never-smoking group.Conclusion: Smoking does not appear to have any influence on TIMP-1 levels in plasma collected from healthy subjects.
Original languageEnglish
JournalInternational Journal of Biological Markers
Volume28
Issue number2
Pages (from-to)226-230
Number of pages5
ISSN0393-6155
DOIs
Publication statusPublished - 28 Jun 2013

ID: 38658404