TY - JOUR
T1 - Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease
T2 - The Copenhagen City Heart Study
AU - Mogelvang, Rasmus
AU - Sogaard, Peter
AU - Pedersen, Sune A.
AU - Olsen, Niels T.
AU - Schnohr, Peter
AU - Jensen, Jan S.
N1 - Funding Information:
This study was supported by grants from the Lundbeck Foundation, the Novo Nordisk Foundation, Manager Boennelycke and Wife’s Foundation, Aase and Ejnar Danielsen’s Foundation, and The Danish Heart Foundation (7-10-R60-A1698-B132-22413), Copenhagen, Denmark.
PY - 2009/3
Y1 - 2009/3
N2 - AimsTo test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population.Methods and resultsWithin a large, community-based population study, cardiac function was evaluated in 1036 participants by both conventional echocardiography and colour TDI. Peak systolic (s′) and early diastolic (e′) velocities, longitudinal displacement (LD), and the ratio of mitral inflow E-wave to e′ (E/e′) were measured. TDI revealed significantly impaired parameters of systolic and diastolic cardiac function in hypertension [n = 345; LD 10.1 (±standard deviation, SD 2.0 mm), P < 0.001; E/e′ 12.4 (×÷SD 1.4), P < 0.001], diabetes [n = 65; LD 9.8 (±SD 2.2 mm), P < 0.001; E/e′ 12.7 (×÷SD 1.5), P < 0.001], and IHD [n = 93; LD 9.4 (±SD 2.5 mm), P < 0.001; E/e′ 13.0 (×÷SD 1.5), P < 0.001] compared with controls [n = 533; LD 11.4 (±SD 2.0 mm); E/e′ 9.0 (×÷SD 1.3)]. This pattern remained significant after adjusting for age, sex, body mass index, heart rate, and the results of conventional echocardiography.ConclusionIn the general population, persons with hypertension, diabetes, or IHD have impaired cardiac function by TDI independently of the result of conventional echocardiography.
AB - AimsTo test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population.Methods and resultsWithin a large, community-based population study, cardiac function was evaluated in 1036 participants by both conventional echocardiography and colour TDI. Peak systolic (s′) and early diastolic (e′) velocities, longitudinal displacement (LD), and the ratio of mitral inflow E-wave to e′ (E/e′) were measured. TDI revealed significantly impaired parameters of systolic and diastolic cardiac function in hypertension [n = 345; LD 10.1 (±standard deviation, SD 2.0 mm), P < 0.001; E/e′ 12.4 (×÷SD 1.4), P < 0.001], diabetes [n = 65; LD 9.8 (±SD 2.2 mm), P < 0.001; E/e′ 12.7 (×÷SD 1.5), P < 0.001], and IHD [n = 93; LD 9.4 (±SD 2.5 mm), P < 0.001; E/e′ 13.0 (×÷SD 1.5), P < 0.001] compared with controls [n = 533; LD 11.4 (±SD 2.0 mm); E/e′ 9.0 (×÷SD 1.3)]. This pattern remained significant after adjusting for age, sex, body mass index, heart rate, and the results of conventional echocardiography.ConclusionIn the general population, persons with hypertension, diabetes, or IHD have impaired cardiac function by TDI independently of the result of conventional echocardiography.
KW - Diabetes mellitus
KW - Echocardiography
KW - Hypertension
KW - Ischaemic heart disease
KW - Population
KW - Tissue Doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=64949162717&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehn596
DO - 10.1093/eurheartj/ehn596
M3 - Journal article
C2 - 19176536
AN - SCOPUS:64949162717
SN - 0195-668X
VL - 30
SP - 731
EP - 739
JO - European Heart Journal
JF - European Heart Journal
IS - 6
ER -