Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Time course of symptoms in posttraumatic stress disorder with delayed expression: a systematic review

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Weight gain on antipsychotics – A perfect storm of complex pathophysiology and psychopharmacology

    Research output: Contribution to journalLetterResearchpeer-review

  2. Autism comorbidities show elevated female-to-male odds ratios and are associated with the age of first autism diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Number of Traumatic brain injuries and temporal associations with depression: A register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Severe mental illness is associated with increased mortality and severe course of COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-Term Risk of Developing Dementia After Electroconvulsive Therapy for Affective Disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Unipolar psychotic depression

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Selvskade er et stigende problem, men der er håb forude

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To examine the hypothesis that PTSD with delayed expression in some cases occurs without subthreshold PTSD symptoms above background levels bridging the gap between the traumatic exposure(s) and the clinical diagnosis.

METHODS: We performed systematic searches of peer-reviewed papers in English referenced in Pubmed, Embase, or PsycINFO and ascertained 34 prospective studies of PTSD symptom trajectories identified by latent class growth statistical modeling. Studies with delayed and low-stable trajectories provided appropriate data for this study. We computed the difference between the delayed trajectory PTSD symptom sumscore and the low-stable PTSD sumscore at the observed points in time after the traumatic event(s).

RESULTS: In 29 study populations, the latent class growth analyses displayed delayed trajectories, and in these, we identified 110 data points (% PTSD sumscore difference/months since traumatic exposure). The median PTSD symptom sumscore was 25% higher during the initial 6 months among individuals in the delayed trajectory compared to those in low-stable trajectory. From this level, the difference widened and reached a plateau of 40-50% higher. The variation was large, and the baseline participation rate and loss to follow-up were exceeding 25% in the majority of the studies. Heterogeneity of populations, measures, and analyses precluded formal meta-analysis.

CONCLUSION: Delayed PTSD is preceded by PTSD symptoms during the first year in most cases. Still, few individuals may experience an asymptomatic delay. The results underpin the rationale for monitoring PTSD symptoms and may inform forensic assessments in that delayed PTSD without symptoms bridging the traumatic event is rare.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
ISSN0001-690X
DOIs
Publication statusE-pub ahead of print - 15 Sep 2021

Bibliographical note

This article is protected by copyright. All rights reserved.

ID: 67833155