Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus

Luca Giovanella; Federica D'Aurizio; Alicia Algeciras-Schimnich; Rainer Görges; Petra Petranovic Ovcaricek; R Michael Tuttle; W Edward Visser; Frederik A Verburg; hsTg&TgAb Consensus Working Group; Ulla  Feldt-Rasmussen

doi:10.1093/ejendo/lvad109

Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus

Luca Giovanella^*, Federica D'Aurizio, Alicia Algeciras-Schimnich, Rainer Görges, Petra Petranovic Ovcaricek, R Michael Tuttle, W Edward Visser, Frederik A Verburg, hsTg&TgAb Consensus Working Group , Ulla Feldt-Rasmussen (Member of author group)

^*Corresponding author for this work

43 Citations (Scopus)

Abstract

OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results.

DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues.

METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature.

RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately.

CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.

Original language	English
Journal	European Journal of Endocrinology
Volume	189
Issue number	2
Pages (from-to)	R11-R27
ISSN	0804-4643
DOIs	https://doi.org/10.1093/ejendo/lvad109
Publication status	Published - 2 Aug 2023

Keywords

Humans
Consensus
Thyroid Neoplasms/diagnosis
Autoantibodies
Adenocarcinoma
follow-up
highly-sensitive thyroglobulin measurements
anti-thyroglobulin antibodies
differentiated thyroid cancer

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10.1093/ejendo/lvad109

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Giovanella, L., D'Aurizio, F., Algeciras-Schimnich, A., Görges, R., Petranovic Ovcaricek, P., Tuttle, R. M., Visser, W. E., Verburg, F. A., hsTg&TgAb Consensus Working Group , & Feldt-Rasmussen, U. (2023). Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus. European Journal of Endocrinology, 189(2), R11-R27. https://doi.org/10.1093/ejendo/lvad109

Giovanella, L, D'Aurizio, F, Algeciras-Schimnich, A, Görges, R, Petranovic Ovcaricek, P, Tuttle, RM, Visser, WE, Verburg, FA, hsTg&TgAb Consensus Working Group & Feldt-Rasmussen, U 2023, 'Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus', European Journal of Endocrinology, vol. 189, no. 2, pp. R11-R27. https://doi.org/10.1093/ejendo/lvad109

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title = "Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus",

abstract = "OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results.DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues.METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature.RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately.CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.",

keywords = "Humans, Consensus, Thyroid Neoplasms/diagnosis, Autoantibodies, Adenocarcinoma, follow-up, highly-sensitive thyroglobulin measurements, anti-thyroglobulin antibodies, differentiated thyroid cancer",

author = "Luca Giovanella and Federica D'Aurizio and Alicia Algeciras-Schimnich and Rainer G{\"o}rges and \{Petranovic Ovcaricek\}, Petra and Tuttle, \{R Michael\} and Visser, \{W Edward\} and Verburg, \{Frederik A\} and \{hsTg\&TgAb Consensus Working Group\} and Ulla Feldt-Rasmussen",

note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology.",

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month = aug,

day = "2",

doi = "10.1093/ejendo/lvad109",

language = "English",

volume = "189",

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TY - JOUR

T1 - Thyroglobulin and thyroglobulin antibody

T2 - an updated clinical and laboratory expert consensus

AU - Giovanella, Luca

AU - D'Aurizio, Federica

AU - Algeciras-Schimnich, Alicia

AU - Görges, Rainer

AU - Petranovic Ovcaricek, Petra

AU - Tuttle, R Michael

AU - Visser, W Edward

AU - Verburg, Frederik A

AU - hsTg&TgAb Consensus Working Group

A2 - Feldt-Rasmussen, Ulla

N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology.

PY - 2023/8/2

Y1 - 2023/8/2

N2 - OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results.DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues.METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature.RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately.CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.

AB - OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results.DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues.METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature.RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately.CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.

KW - Humans

KW - Consensus

KW - Thyroid Neoplasms/diagnosis

KW - Autoantibodies

KW - Adenocarcinoma

KW - follow-up

KW - highly-sensitive thyroglobulin measurements

KW - anti-thyroglobulin antibodies

KW - differentiated thyroid cancer

UR - https://www.scopus.com/pages/publications/85168715483

U2 - 10.1093/ejendo/lvad109

DO - 10.1093/ejendo/lvad109

M3 - Journal article

C2 - 37625447

SN - 0804-4643

VL - 189

SP - R11-R27

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 2

ER -

Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus

Abstract

Keywords

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