Thyroglobulin and thyroglobulin antibody: an updated clinical and laboratory expert consensus

Luca Giovanella*, Federica D'Aurizio, Alicia Algeciras-Schimnich, Rainer Görges, Petra Petranovic Ovcaricek, R Michael Tuttle, W Edward Visser, Frederik A Verburg, hsTg&TgAb Consensus Working Group , Ulla Feldt-Rasmussen (Member of study group)

*Corresponding author for this work
    13 Citations (Scopus)

    Abstract

    OBJECTIVE: Thyroglobulin measurement is the cornerstone of modern management of differentiated thyroid cancer, with clinical decisions on treatment and follow-up based on the results of such measurements. However, numerous factors need to be considered regarding measurement with and interpretation of thyroglobulin assay results.

    DESIGN: The present document provides an integrated update to the 2013 and 2014 separate clinical position papers of our group on these issues.

    METHODS: Issues concerning analytical and clinical aspects of highly-sensitive thyroglobulin measurement will be reviewed and discussed based on an extensive analysis of the available literature.

    RESULTS: Thyroglobulin measurement remains a highly complex process with many pitfalls and major sources of interference, especially anti-thyroglobulin antibodies, need to be assessed, considered and, when necessary, dealt with appropriately.

    CONCLUSIONS: Our expert consensus group formulated 53 practical, graded recommendations for guidance on highly-sensitive thyroglobulin and TgAb in laboratory and clinical practice, especially valuable where current guidelines do not offer sufficient guidance.

    Original languageEnglish
    JournalEuropean Journal of Endocrinology
    Volume189
    Issue number2
    Pages (from-to)R11-R27
    ISSN0804-4643
    DOIs
    Publication statusPublished - 2 Aug 2023

    Keywords

    • Humans
    • Consensus
    • Thyroid Neoplasms/diagnosis
    • Autoantibodies
    • Adenocarcinoma
    • follow-up
    • highly-sensitive thyroglobulin measurements
    • anti-thyroglobulin antibodies
    • differentiated thyroid cancer

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