1 Citation (Scopus)

Abstract

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity.

METHODS: We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

RESULTS: TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p = .03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p = .04), monocytes (rho = 0.58, p = .006), and lymphocytes (rho = 0.59, p = .02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p = .01).

CONCLUSION: In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

Original languageEnglish
JournalImmunopharmacology and Immunotoxicology
Volume44
Issue number6
Pages (from-to)1004-1012
Number of pages9
ISSN0892-3973
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Hematopoietic Stem Cell Transplantation/adverse effects
  • Humans
  • Immune Reconstitution
  • Thymic Stromal Lymphopoietin
  • Thymic stromal lymphopoietin
  • chronic GvHD
  • hematopoietic stem cell transplantation
  • immune reconstitution
  • alloreactivity

Fingerprint

Dive into the research topics of 'Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation'. Together they form a unique fingerprint.

Cite this