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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Thromboembolic Complications in Fontan Patients: Population-Based Prevalence and Exploration of the Etiology

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After the Fontan procedure, patients face an increased risk for thromboembolic events (TE). The etiology for this increased thrombogenecity is incompletely understood. This study aimed to determine the prevalence of TE in Danish Fontan patients and to bring new insights into the etiology of TE. Using a population-based design, we retrospectively identified all TEs in 210 Fontan patients. Whole blood assays (thromboelastography, thromboelastography functional fibrinogen and Multiplate) reflecting global hemostasis, clot strength and platelet aggregation were analyzed prospectively in 112 patients and plasma was analyzed in 76 patients for biomarkers reflecting endothelial-, glycocalyx-, platelet-, and fibrinolysis function (histone-complexed DNA fragments, Protein C, soluble CD40 ligand, soluble thrombomodulin, syndecan-1, tissue-type plasminogen activator). The results were compared in groups stratified according to age, antithrombotic therapy, TE, and glycocalyx degradation (syndecan-1 
Original languageEnglish
JournalAnnals of Pediatric Cardiology
Volume34
Issue number2
Pages (from-to)262-72
ISSN0974-2069
DOIs
Publication statusPublished - 2013

ID: 36811775