Thrombin-receptor antagonist vorapaxar in acute coronary syndromes

Pierluigi Tricoci; Zhen Huang; Claes Held; David J Moliterno; Paul W Armstrong; Frans Van de Werf; Harvey D White; Philip E Aylward; Lars Wallentin; Edmond Chen; Yuliya Lokhnygina; Jinglan Pei; Sergio Leonardi; Tyrus L Rorick; Ann M Kilian; Lisa H K Jennings; Giuseppe Ambrosio; Christoph Bode; Angel Cequier; Jan H Cornel; Rafael Diaz; Aycan Erkan; Kurt Huber; Michael P Hudson; Lixin Jiang; J Wouter Jukema; Basil S Lewis; A Michael Lincoff; Gilles Montalescot; José Carlos Nicolau; Hisao Ogawa; Matthias Pfisterer; Juan Carlos Prieto; Witold Ruzyllo; Peter R Sinnaeve; Robert F Storey; Marco Valgimigli; David J Whellan; Petr Widimsky; John Strony; Robert A Harrington; Kenneth W Mahaffey; TRACER Investigators; Peer Grande; Søren Galatius

doi:10.1056/NEJMoa1109719

Thrombin-receptor antagonist vorapaxar in acute coronary syndromes

Pierluigi Tricoci, Zhen Huang, Claes Held, David J Moliterno, Paul W Armstrong, Frans Van de Werf, Harvey D White, Philip E Aylward, Lars Wallentin, Edmond Chen, Yuliya Lokhnygina, Jinglan Pei, Sergio Leonardi, Tyrus L Rorick, Ann M Kilian, Lisa H K Jennings, Giuseppe Ambrosio, Christoph Bode, Angel Cequier, Jan H CornelRafael Diaz, Aycan Erkan, Kurt Huber, Michael P Hudson, Lixin Jiang, J Wouter Jukema, Basil S Lewis, A Michael Lincoff, Gilles Montalescot, José Carlos Nicolau, Hisao Ogawa, Matthias Pfisterer, Juan Carlos Prieto, Witold Ruzyllo, Peter R Sinnaeve, Robert F Storey, Marco Valgimigli, David J Whellan, Petr Widimsky, John Strony, Robert A Harrington, Kenneth W Mahaffey, TRACER Investigators, Peer Grande, Søren Galatius

728 Citations (Scopus)

Abstract

Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation.

Original language	English
Journal	New England Journal of Medicine
Volume	366
Issue number	1
Pages (from-to)	20-33
Number of pages	14
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1109719
Publication status	Published - 2012

Keywords

Acute Coronary Syndrome
Aged
Angioplasty
Cardiovascular Diseases
Combined Modality Therapy
Coronary Artery Bypass
Double-Blind Method
Drug Therapy, Combination
Female
Follow-Up Studies
Hemorrhage
Humans
Intracranial Hemorrhages
Kaplan-Meier Estimate
Lactones
Male
Middle Aged
Platelet Aggregation Inhibitors
Pyridines
Receptor, PAR-1

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10.1056/NEJMoa1109719

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Tricoci, P., Huang, Z., Held, C., Moliterno, D. J., Armstrong, P. W., Van de Werf, F., White, H. D., Aylward, P. E., Wallentin, L., Chen, E., Lokhnygina, Y., Pei, J., Leonardi, S., Rorick, T. L., Kilian, A. M., Jennings, L. H. K., Ambrosio, G., Bode, C., Cequier, A., ... Galatius, S. (2012). Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. New England Journal of Medicine, 366(1), 20-33. https://doi.org/10.1056/NEJMoa1109719

Tricoci, P, Huang, Z, Held, C, Moliterno, DJ, Armstrong, PW, Van de Werf, F, White, HD, Aylward, PE, Wallentin, L, Chen, E, Lokhnygina, Y, Pei, J, Leonardi, S, Rorick, TL, Kilian, AM, Jennings, LHK, Ambrosio, G, Bode, C, Cequier, A, Cornel, JH, Diaz, R, Erkan, A, Huber, K, Hudson, MP, Jiang, L, Jukema, JW, Lewis, BS, Lincoff, AM, Montalescot, G, Nicolau, JC, Ogawa, H, Pfisterer, M, Prieto, JC, Ruzyllo, W, Sinnaeve, PR, Storey, RF, Valgimigli, M, Whellan, DJ, Widimsky, P, Strony, J, Harrington, RA, Mahaffey, KW, TRACER Investigators, Grande, P & Galatius, S 2012, 'Thrombin-receptor antagonist vorapaxar in acute coronary syndromes', New England Journal of Medicine, vol. 366, no. 1, pp. 20-33. https://doi.org/10.1056/NEJMoa1109719

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title = "Thrombin-receptor antagonist vorapaxar in acute coronary syndromes",

abstract = "Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation.",

keywords = "Acute Coronary Syndrome, Aged, Angioplasty, Cardiovascular Diseases, Combined Modality Therapy, Coronary Artery Bypass, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Hemorrhage, Humans, Intracranial Hemorrhages, Kaplan-Meier Estimate, Lactones, Male, Middle Aged, Platelet Aggregation Inhibitors, Pyridines, Receptor, PAR-1",

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AU - Armstrong, Paul W

AU - Van de Werf, Frans

AU - White, Harvey D

AU - Aylward, Philip E

AU - Wallentin, Lars

AU - Chen, Edmond

AU - Lokhnygina, Yuliya

AU - Pei, Jinglan

AU - Leonardi, Sergio

AU - Rorick, Tyrus L

AU - Kilian, Ann M

AU - Jennings, Lisa H K

AU - Ambrosio, Giuseppe

AU - Bode, Christoph

AU - Cequier, Angel

AU - Cornel, Jan H

AU - Diaz, Rafael

AU - Erkan, Aycan

AU - Huber, Kurt

AU - Hudson, Michael P

AU - Jiang, Lixin

AU - Jukema, J Wouter

AU - Lewis, Basil S

AU - Lincoff, A Michael

AU - Montalescot, Gilles

AU - Nicolau, José Carlos

AU - Ogawa, Hisao

AU - Pfisterer, Matthias

AU - Prieto, Juan Carlos

AU - Ruzyllo, Witold

AU - Sinnaeve, Peter R

AU - Storey, Robert F

AU - Valgimigli, Marco

AU - Whellan, David J

AU - Widimsky, Petr

AU - Strony, John

AU - Harrington, Robert A

AU - Mahaffey, Kenneth W

AU - TRACER Investigators

AU - Grande, Peer

AU - Galatius, Søren

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KW - Acute Coronary Syndrome

KW - Aged

KW - Angioplasty

KW - Cardiovascular Diseases

KW - Combined Modality Therapy

KW - Coronary Artery Bypass

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Female

KW - Follow-Up Studies

KW - Hemorrhage

KW - Humans

KW - Intracranial Hemorrhages

KW - Kaplan-Meier Estimate

KW - Lactones

KW - Male

KW - Middle Aged

KW - Platelet Aggregation Inhibitors

KW - Pyridines

KW - Receptor, PAR-1

UR - https://www.scopus.com/pages/publications/83655177669

U2 - 10.1056/NEJMoa1109719

DO - 10.1056/NEJMoa1109719

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C2 - 22077816

SN - 0028-4793

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SP - 20

EP - 33

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 1

ER -

Thrombin-receptor antagonist vorapaxar in acute coronary syndromes

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Keywords

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