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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Thrombelastography Early Amplitudes in bleeding and coagulopathic trauma patients: Results from a multicenter study

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BACKGROUND: Early amplitudes in the viscoelastic hemostatic assays Thrombelastography (TEG) and Rotation Thromboelastometry (ROTEM) provide fast results, which is critical in resuscitation of bleeding patients. This study investigated associations between TEG early amplitudes and standard TEG variables in a large multicenter cohort of moderately to severely injured trauma patients admitted at three North European level 1 Trauma Centers.

METHODS: Prospective observational study of 404 trauma patients with clinical suspicion of severe injury from London, UK, Copenhagen, Denmark and Oslo, Norway. Biochemistry and clinical data including outcome and TEG parameters were recorded upon arrival. Kaolin TEG, Rapid TEG, and TEG functional fibrinogen curves were extracted, and early amplitudes A5 and A10 (amplitude at 5 and 10 min) were registered. Patients were stratified according to international normalized ratio (INR) ≤1.2 or >1.2, as well as transfusion requirements (non-transfused, 1-9 RBC units and ≥10 RBC units in 12 hours).

RESULTS: In total 404 patients were included, median ISS was 13. There were strong positive correlations between A5/A10 and maximum amplitude in all investigated assays. All TEG values except rTEG MA and kTEG MA correlated significantly with mortality in transfused patients. Time from initiation of assay to A5 and A10 were lowest for Rapid TEG and TEG functional fibrinogen compared to Kaolin TEG. Rapid TEG A5 reduced time to result with >50% compared to Rapid TEG maximum amplitude.

CONCLUSIONS: We found strong associations between TEG early amplitudes A5/A10 and maximum amplitude in rapid TEG, kaolin TEG and TEG Functional Fibrinogen across trauma patients with coagulopathy and massive transfusion requirements. Introducing the use of early amplitudes can reduce time to diagnosis of coagulopathy and may be used in TEG-monitoring of trauma patient. Further randomized controlled trials evaluating the role of TEG in guiding hemostatic resuscitation are warranted.

LEVEL OF EVIDENCE: Prognostic and diagnostic study, level III.

Original languageEnglish
JournalThe journal of trauma and acute care surgery
Volume84
Issue number2
Pages (from-to)334-341
ISSN2163-0755
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52002895