Thrombelastography and Conventional Coagulation Markers in Chronic Obstructive Pulmonary Disease: A Prospective Paired-Measurements Study Comparing Exacerbation and Stable Phases

Ema Rastoder, Peter Kamstrup, Caroline Hedsund, Alexander Jordan, Pradeesh Sivapalan, Valdemar Rømer, Frederikke Falkvist, Sadaf Hamidi, Elisabeth Bendstrup, Søren Sperling, Maria Dons, Tor Biering-Sørensen, Casper Falster, Christian B. Laursen, Jørn Carlsen, Jens Ulrik Stæhr Jensen*

*Corresponding author for this work

Abstract

Chronic Obstructive Pulmonary Disease (COPD) exacerbation is known for its substantial impact on morbidity and mortality among affected patients, creating a significant healthcare burden worldwide. Coagulation abnormalities have emerged as potential contributors to exacerbation pathogenesis, raising concerns about increased thrombotic events during exacerbation. The aim of this study was to explore the differences in thrombelastography (TEG) parameters and coagulation markers in COPD patients during admission with exacerbation and at a follow-up after discharge. This was a multi-center cohort study. COPD patients were enrolled within 72 h of hospitalization. The baseline assessments were Kaolin-TEG and blood samples. Statistical analysis involved using descriptive statistics; the main analysis was a paired t-test comparing coagulation parameters between exacerbation and follow-up. One hundred patients participated, 66% of whom were female, with a median age of 78.5 years and comorbidities including atrial fibrillation (18%) and essential arterial hypertension (45%), and sixty-five individuals completed a follow-up after discharge. No significant variations were observed in Kaolin-TEG or conventional coagulation markers between exacerbation and follow-up. The Activated Partial Thromboplastin Clotting Time (APTT) results were near-significant, with p = 0.08. In conclusion, TEG parameters displayed no significant alterations between exacerbation and follow-up.

Original languageEnglish
Article number2051
JournalInternational Journal of Molecular Sciences
Volume25
Issue number4
Number of pages12
ISSN1661-6596
DOIs
Publication statusPublished - Feb 2024

Keywords

  • COPD
  • exacerbation
  • thrombelastography

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