Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Thresholds for clinical importance were defined for the European Organisation for Research and Treatment of Cancer Computer Adaptive Testing Core-an adaptive measure of core quality of life domains in oncology clinical practice and research

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ecological momentary assessments (EMAs) did not improve responsiveness of patient-reported outcomes on quality of life

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Half of Cochrane reviews were published more than 2 years after the protocol

    Research output: Contribution to journalReviewResearchpeer-review

  3. Unlike ROC analysis, a new IRT method identified clinical thresholds unbiased by disease prevalence

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Systematic review finds that appraisal tools for medical research studies address conflicts of interest superficially

    Research output: Contribution to journalReviewResearchpeer-review

  1. International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Integration af specialiseret palliation og onkologi

    Research output: Contribution to journalJournal articleResearchpeer-review

  • EORTC Quality of Life Group
View graph of relations

OBJECTIVES: The aim of this article was to establish thresholds for clinical importance (TCIs) for the European Organisation for Research and Treatment of Cancer (EORTC) Computer Adaptive Testing (CAT) Core measure, the new adaptive version of the EORTC QLQ-C30.

STUDY DESIGN AND SETTING: For our diagnostic study, we recruited cancer patients with mixed diagnoses and treatments from six European countries. Patients completed the EORTC CAT Core and a questionnaire with anchor items assessing criteria for clinical importance (limitations in everyday life, need for help/care, and worries by the patient/family/partner) for each EORTC CAT Core domain. We used a binary variable summarizing the anchor items for determining TCIs and for calculating the area under the curve (AUC) in receiving operator characteristic analysis as a measure of diagnostic accuracy.

RESULTS: Using data from 498 cancer patients (mean age 60.4 years, 55.2% women), we established TCIs for the 14 domains of the EORTC CAT Core. Median AUC across domains was 0.93 (range 0.84-0.94). Median sensitivity and specificity of the TCIs were 0.91 (range 0.80-0.96) and 0.77 (range 0.66-0.84), respectively. TCIs and AUCs were largely consistent across patient groups.

CONCLUSION: We have generated TCIs for the 14 functional health and symptom domains of the EORTC CAT Core. The EORTC CAT Core showed high diagnostic accuracy in identifying clinically important symptoms and functional impairments.

Original languageEnglish
JournalJournal of Clinical Epidemiology
Volume117
Pages (from-to)117-125
Number of pages9
ISSN0895-4356
DOIs
Publication statusPublished - 5 Jan 2020

ID: 58891213