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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Threshold altitude for bubble decay and stabilization in rat adipose tissue at hypobaric exposures

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  1. Voluntary respiratory control and cerebral blood flow velocity upon ice-water immersion

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  2. Reduced cerebral perfusion on sudden immersion in ice water: a possible cause of drowning

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  1. Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection

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  2. Effect of immunoglobulin G on cytokine response in necrotising soft-tissue infection: a post-hoc analysis

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  3. Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

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  4. Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

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Bubble formation during altitude exposures, causing altitude decompression sickness (aDCS), has been referred to in theoretical models as venous gas embolisms (VGE). This has also been demonstrated by intravascular gas formation. Previous reports indicate that the formation of VGE and aDCS incidence increase abruptly for exposures exceeding 40-44 kPa ambient pressures. Further, extravascular micro air bubbles injected into adipose tissue grow transiently, then shrink and disappear while breathing oxygen (F1O2 = 1.0) at 71 kPa. At 25 kPa similar air bubbles will grow and stabilize during oxygen breathing without disappearing. We hypothesize that an ambient pressure threshold for either extravascular bubble stabilization or disappearance may be identified between 71 and 25 kPa. Whether extravascular bubbles will stabilize above a certain threshold has not been demonstrated before.
Original languageEnglish
JournalAviation, Space, and Environmental Medicine
Volume84
Issue number7
Pages (from-to)675-83
Number of pages9
ISSN0095-6562
Publication statusPublished - Jul 2013

    Research areas

  • Abdominal Fat, Adipose Tissue, Air Pressure, Animals, Decompression Sickness, Disease Models, Animal, Embolism, Air, Female, Rats, Rats, Wistar

ID: 41960994