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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Three-dimensional accelerated acquisition for hyperpolarized 13 C MR  with blipped stack-of-spirals and conjugate-gradient  SENSE

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  • Rie B Olin
  • Juan Diego Sánchez-Heredia
  • Rolf F Schulte
  • Nikolaj Bøgh
  • Esben Søvsø Szocska Hansen
  • Christoffer Laustsen
  • Lars G Hanson
  • Jan H Ardenkjaer-Larsen
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PURPOSE: To test a new parallel imaging strategy for acceleration of hyperpolarized 13 C MR acquisitions based on a 3D blipped stack-of-spirals trajectory and conjugate-gradient SENSE reconstruction with precalibrated sensitivities.

METHODS: The blipped stack-of-spirals trajectory was developed for an acceleration factor of 4, based on an undersampled stack-of-spirals with gradient blips during spiral readout. The trajectory was developed with volumetric coverage of a large FOV and with high spatial resolution. High temporal resolution was attained through spectral-spatial excitation and 4 excitations per volume. The blipped stack-of-spirals was evaluated in simulations and phantom experiments. Next, the method was evaluated for kidney and cardiac imaging in 2 separate healthy pigs.

RESULTS: Simulation and phantom results showed successful acquisition and reconstruction, but also revealed reconstruction challenges for certain locations and for wide signal sources. For the kidney experiment, the accelerated acquisition showed high similarity to 2 separately acquired fully sampled data sets with matched spatial and temporal resolution, respectively. For the cardiac experiment, the accelerated acquisition proved able to map each metabolite in 3 dimensions within a single cardiac cycle.

CONCLUSION: The proposed method demonstrated effective mapping of metabolism in both kidneys and the heart of healthy pigs. Limitations seen in phantom experiments, may be irrelevant for most clinical applications, but should be kept in mind as well as reconstruction challenges related to residual aliasing. All in all, we show that the blipped stack-of-spirals is a relevant parallel imaging method for hyperpolarized human imaging, facilitating better insights into metabolism compared with nonaccelerated acquisition.

Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume84
Issue number2
Pages (from-to)519-534
Number of pages16
ISSN0740-3194
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • C MRI, 3D imaging, hyperpolarization, metabolic imaging, parallel imaging

ID: 59121037