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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

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  • Nicolaj Brandt
  • Lene H Garvey
  • Ulla Bindslev-Jensen
  • Henrik Fomsgaard Kjaer
  • Carsten Bindslev-Jensen
  • Charlotte G Mortz
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We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

Original languageEnglish
JournalClinical and translational allergy
Volume7
Pages (from-to)2
ISSN2045-7022
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

ID: 52696799