Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

The validity of daily patient-reported anxiety measured using smartphones and the association with stress, quality of life and functioning in patients with bipolar disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: A randomized placebo-controlled study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: More than half of patients with bipolar disorder (BD) experience anxiety, which is associated with impaired functioning. In patients with BD, the present study aimed (1) to validate daily patient-reported symptoms of anxiety measured using smartphones against clinically rated symptoms of anxiety, (2) to estimate the prevalence of anxiety symptoms, and (3) to investigate the associations between patient-reported anxiety symptoms and stress, quality of life and functioning.

METHODS: A total of 84 patients with BD evaluated their anxiety symptoms daily for nine months using a smartphone-based system. Data on clinically evaluated symptoms of anxiety and functioning and patient-reported stress and quality of life were collected from each patient at five fixed time points during follow-up.

RESULTS: The patients presented mild affective symptoms only. The reporting of anxiety symptoms was evaluated for validity according to clinically evaluated anxiety scores based on the two anxiety sub-items of the Hamilton Depression Rating Scale. The patients experienced symptoms of anxiety 19.3% of the time. There were statistically significant associations between anxiety and stress, quality of life and functioning (all p-values < 0.0001).

CONCLUSION: In patients with BD in full or partial remission, the self-reporting of anxiety symptoms using smartphones was validated. Anxiety is associated with increased stress, decreased quality of life and functioning even during full or partial remission. Identifying anxiety symptoms thus has clinical impact, which suggests that smartphones may serve as a valid tool.

Original languageEnglish
JournalJournal of Affective Disorders
Pages (from-to)100-107
Number of pages8
Publication statusPublished - 1 Oct 2019

ID: 58077641