Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal

    Research output: Contribution to journalJournal articleResearch

  3. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Light- and electron microscopical studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Catheter ablation of atypical flutter using new 3-dimensional electroanatomic mapping software focusing on areas of conduction block

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Collagen density regulates the activity of tumor-infiltrating T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The urokinase plasminogen activator receptor-associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and collagen V on the cell surface. We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V.

Original languageEnglish
JournalLaboratory investigation; a journal of technical methods and pathology
Volume81
Issue number10
Pages (from-to)1403-14
Number of pages12
ISSN0023-6837
Publication statusPublished - Oct 2001

    Research areas

  • Animals, Bone and Bones, Collagenases, Embryonic and Fetal Development, Female, Immunohistochemistry, Matrix Metalloproteinase 13, Mice, Osteogenesis, Pregnancy, Receptors, Cell Surface, Receptors, Mitogen, Receptors, Urokinase Plasminogen Activator

ID: 46435537