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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The targeting of tumor-associated macrophages by vaccination

Research output: Contribution to journalJournal articleResearchpeer-review

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  1. Inflammation induced PD-L1-specific T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Arginase 1-based immune modulatory vaccines induce anti-cancer immunity and synergize with anti-PD-1 checkpoint blockade

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  2. Lynch syndrome-associated epithelial ovarian cancer and its immunological profile

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  3. ABO blood types and sepsis mortality

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  4. Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

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Many different therapeutic strategies focus on targeting tumor-associated macrophages (TAMs), due to their vital role in creating an immune suppressive tumor microenvironment (TME) with the aim to deplete, repro-gram or target the functional mediators secreted by these cells. Immune modulatory vaccination is an emerging strategy to target immune suppressive myeloid populations in the TME. In contrast to the other clinical strategies that target TAMs, this combines both TAM depletion (through direct killing by cytotoxic T cells) and TAM reprogramming (by introducing pro-inflammatory cytokines into the immune suppressive microenvironment).

Original languageEnglish
JournalCell stress
Volume3
Issue number5
Pages (from-to)139-140
Number of pages2
ISSN2523-0204
DOIs
Publication statusPublished - 24 Apr 2019

ID: 57730560