The significance of mitochondrial haplogroups in preeclampsia risk

Kristina Wendelboe Olsen; Paula L Hedley; Christian M Hagen; Line Rode; Sophie Placing; Karen R Wøjdemann; Anne-Cathrine Shalmi; Karin Sundberg; Anne Nørremølle; Ann Tabor; Joanna L Elson; Michael Christiansen

doi:10.1016/j.preghy.2023.11.001

The significance of mitochondrial haplogroups in preeclampsia risk

Kristina Wendelboe Olsen, Paula L Hedley, Christian M Hagen, Line Rode, Sophie Placing, Karen R Wøjdemann, Anne-Cathrine Shalmi, Karin Sundberg, Anne Nørremølle, Ann Tabor, Joanna L Elson^*, Michael Christiansen

^*Corresponding author for this work

Abstract

OBJECTIVE: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.

METHODS: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.

RESULTS: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.

CONCLUSION: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

Original language	English
Journal	Pregnancy Hypertension
Volume	34
Pages (from-to)	146-151
Number of pages	6
ISSN	2210-7789
DOIs	https://doi.org/10.1016/j.preghy.2023.11.001
Publication status	Published - 2023

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10.1016/j.preghy.2023.11.001

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title = "The significance of mitochondrial haplogroups in preeclampsia risk",

abstract = "OBJECTIVE: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODS: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTS: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSION: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.",

author = "{Wendelboe Olsen}, Kristina and Hedley, {Paula L} and Hagen, {Christian M} and Line Rode and Sophie Placing and W{\o}jdemann, {Karen R} and Anne-Cathrine Shalmi and Karin Sundberg and Anne N{\o}rrem{\o}lle and Ann Tabor and Elson, {Joanna L} and Michael Christiansen",

year = "2023",

doi = "10.1016/j.preghy.2023.11.001",

language = "English",

volume = "34",

pages = "146--151",

journal = "Pregnancy Hypertension",

issn = "2210-7789",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - The significance of mitochondrial haplogroups in preeclampsia risk

AU - Wendelboe Olsen, Kristina

AU - Hedley, Paula L

AU - Hagen, Christian M

AU - Rode, Line

AU - Placing, Sophie

AU - Wøjdemann, Karen R

AU - Shalmi, Anne-Cathrine

AU - Sundberg, Karin

AU - Nørremølle, Anne

AU - Tabor, Ann

AU - Elson, Joanna L

AU - Christiansen, Michael

PY - 2023

Y1 - 2023

N2 - OBJECTIVE: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODS: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTS: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSION: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

AB - OBJECTIVE: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODS: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTS: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSION: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

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U2 - 10.1016/j.preghy.2023.11.001

DO - 10.1016/j.preghy.2023.11.001

M3 - Journal article

C2 - 37979242

SN - 2210-7789

VL - 34

SP - 146

EP - 151

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

ER -

The significance of mitochondrial haplogroups in preeclampsia risk

Abstract

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