The serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro.

P Afzelius, S D Nielsen, B Hofmann, Jens Ole Nielsen

13 Citations (Scopus)

Abstract

HIV infection is characterized by the loss of CD4+ T cell numbers as well as loss of T cell function leading to severe immunodeficiency. The proliferative capacity of T cells, measured in vitro as response to antigens and mitogens, is severely reduced during HIV infection. An increased level of the intracellular second messenger cAMP has been demonstrated to cause impaired proliferative capacity of PBMC from HIV-infected individuals in vitro. We have identified a serotonin analogue, buspirone, that inhibits the activity of adenylyl cyclase, the enzyme responsible for regulation of intracellular levels of cAMP. Using this inhibitor the proliferative responses of PBMC to a polyclone activator in vitro were increased in 28/30 HIV-seropositive individuals (p < 0.00001). Further, we demonstrated that this was due to proliferation of CD4+ T cells and that buspirone induced expression of IL-2 mRNA.
Translated title of the contributionThe serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro.
Original languageEnglish
JournalScandinavian Journal of Infectious Diseases
Volume29
Issue number2
Pages (from-to)117-120
Number of pages4
ISSN0036-5548
Publication statusPublished - 1997

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