Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

The sensitivity of fecal calprotectin in predicting deep remission in ulcerative colitis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. 3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography - a future method?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Colonoscopy adverse events: are we getting the full picture?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pathophysiological-based treatments of complications of cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. MicroRNA Biomarkers in IBD-Differential Diagnosis and Prediction of Colitis-Associated Cancer

    Research output: Contribution to journalReviewResearchpeer-review

  2. Extraintestinal Manifestations are Associated with Disease Severity in Pediatric Onset Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

BACKGROUND: Mucosal healing is proposed as treat-to-target in ulcerative colitis (UC), even though the definition of mucosal healing remains contested as it has been suggested to be assessed by either endoscopy, histology or both. However, all definitions require an endoscopic evaluation of the mucosa. As endoscopies are invasive and uncomfortable to the patient we aimed to calibrate noninvasive predictors of mucosal inflammatory status defined by both endoscopy and histology.

METHODS: UC patients (n = 106) undergoing a sigmoid-/colonoscopy were prospectively included. Feces (fecal calprotectin, FC), blood samples (hemoglobin, C-reactive protein, orosomucoid, erythrocyte sedimentation rate, albumin) and symptom scores (Simple Clinical Colitis Activity Index, SSCAI) were collected and analyzed. The colonic mucosa was assessed by the Mayo endoscopic sub score and biopsies were obtained for a histologic grading by Geboes score. Predictive cutoff values were analyzed by receiver operating characteristics (ROC). A combined endoscopic and histologic assessment defined deep remission (Mayo =0 and Geboes ≤1) and activity (Mayo ≥2 and Geboes >3).

RESULTS: Only FC showed a significant ROC curve (p < .05). We suggest FC (mg/kg) cutoffs for detection of following: Deep remission: FC ≤25; Indeterminate: FC 25-230 - an endoscopy is recommended if a comprehensive status of both endoscopic and histologic assessed activity is needed; Active disease: FC >230. The complete ROC data is presented, enabling extraction of an FC cutoff value's sensitivity and specificity.

CONCLUSIONS: FC predicts endoscopic and histologic assessed deep remission and inflammatory activity of colon mucosa. Neither the markers in blood nor the SCCAI performed significant ROC results.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Issue number7
Pages (from-to)825-830
Publication statusPublished - 2018

ID: 54747540