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The Safety of Melatonin in Humans

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  2. Type 2 Diabetes Patients Reach Target Glycemic Control Faster Using IDegLira than Either Insulin Degludec or Liraglutide Given Alone

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  3. The T-peak-T-end Interval as a Marker of Repolarization Abnormality: A Comparison with the QT Interval for Five Different Drugs

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  4. Effects of Bilastine on T-wave Morphology and the QTc Interval: A Randomized, Double-Blind, Placebo-Controlled, Thorough QTc Study

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  1. Associations between blood cultures after surgery for colorectal cancer and long-term oncological outcomes

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  2. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

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  3. Incidence of Inguinal Hernia after Radical Prostatectomy: A Systematic Review and Meta-Analysis

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  4. Kønsmodificerende kirurgi i Danmark

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Exogenous melatonin has been investigated as treatment for a number of medical and surgical diseases, demonstrating encouraging results. The aim of this review was to present and evaluate the literature concerning the possible adverse effects and safety of exogenous melatonin in humans. Furthermore, we provide recommendations concerning the possible risks of melatonin use in specific patient groups. In general, animal and human studies documented that short-term use of melatonin is safe, even in extreme doses. Only mild adverse effects, such as dizziness, headache, nausea and sleepiness have been reported. No studies have indicated that exogenous melatonin should induce any serious adverse effects. Similarly, randomized clinical studies indicate that long-term melatonin treatment causes only mild adverse effects comparable to placebo. Long-term safety of melatonin in children and adolescents, however, requires further investigation. Due to a lack of human studies, pregnant and breast-feeding women should not take exogenous melatonin at this moment.

Original languageEnglish
JournalClinical Drug Investigation
Volume36
Issue number3
Pages (from-to)169-75
Number of pages7
ISSN1173-2563
DOIs
Publication statusPublished - Mar 2016

ID: 46493435