The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy-A National Register-Based Study

Shakoor Ba-Ali; Poul Jørgen Jennum; Adam Elias Brøndsted; Steffen Heegaard; Henrik Lund-Andersen

doi:10.3390/jpm13111529

The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy-A National Register-Based Study

Shakoor Ba-Ali^*, Poul Jørgen Jennum, Adam Elias Brøndsted, Steffen Heegaard, Henrik Lund-Andersen

^*Corresponding author for this work

Abstract

INTRODUCTION: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR).

METHODS: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA.

RESULTS: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38-0.50, p < 0.0001).

CONCLUSIONS: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.

Original language	English
Article number	1529
Journal	Journal of Personalized Medicine
Volume	13
Issue number	11
ISSN	2075-4426
DOIs	https://doi.org/10.3390/jpm13111529
Publication status	Published - 25 Oct 2023

Keywords

continuous positive airway pressure
diabetic retinopathy
hypoxia
obstructive sleep apnea

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10.3390/jpm13111529

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title = "The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy-A National Register-Based Study",

abstract = "INTRODUCTION: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR).METHODS: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA.RESULTS: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38-0.50, p < 0.0001).CONCLUSIONS: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.",

keywords = "continuous positive airway pressure, diabetic retinopathy, hypoxia, obstructive sleep apnea",

author = "Shakoor Ba-Ali and Jennum, {Poul J{\o}rgen} and Br{\o}ndsted, {Adam Elias} and Steffen Heegaard and Henrik Lund-Andersen",

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language = "English",

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AU - Ba-Ali, Shakoor

AU - Jennum, Poul Jørgen

AU - Brøndsted, Adam Elias

AU - Heegaard, Steffen

AU - Lund-Andersen, Henrik

PY - 2023/10/25

Y1 - 2023/10/25

N2 - INTRODUCTION: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR).METHODS: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA.RESULTS: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38-0.50, p < 0.0001).CONCLUSIONS: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.

AB - INTRODUCTION: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR).METHODS: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA.RESULTS: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38-0.50, p < 0.0001).CONCLUSIONS: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.

KW - continuous positive airway pressure

KW - diabetic retinopathy

KW - hypoxia

KW - obstructive sleep apnea

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U2 - 10.3390/jpm13111529

DO - 10.3390/jpm13111529

M3 - Journal article

C2 - 38003844

SN - 2075-4426

VL - 13

JO - Journal of Personalized Medicine

JF - Journal of Personalized Medicine

IS - 11

M1 - 1529

ER -

The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy-A National Register-Based Study

Abstract

Keywords

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