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The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

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  • Daniel Tong
  • Anastasia Constantinidou
  • Bodil Engelmann
  • Florence Chamberlain
  • Khin Thway
  • Cyril Fisher
  • Andrew Hayes
  • Nicos Fotiadis
  • Christina Messiou
  • Aisha B Miah
  • Shane H Zaidi
  • Charlotte Benson
  • Winette VAN DER Graaf
  • Robin L Jones
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BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.

PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.

RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.

CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

Original languageEnglish
JournalAnticancer Research
Volume39
Issue number9
Pages (from-to)4891-4896
Number of pages6
ISSN0250-7005
DOIs
Publication statusPublished - Sep 2019
Externally publishedYes

    Research areas

  • Adolescent, Adult, Aged, Combined Modality Therapy, Disease Management, Female, Hemangioendothelioma, Epithelioid/mortality, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Pleural Effusion/pathology, Prognosis, Watchful Waiting, Young Adult

ID: 59280117