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The Role of Leptin in Fetal Growth during Pre-Eclampsia

Research output: Contribution to journalReviewpeer-review

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Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.

Original languageEnglish
Article number4569
JournalInternational Journal of Molecular Sciences
Volume22
Issue number9
Pages (from-to)1-16
Number of pages16
ISSN1661-6596
DOIs
Publication statusPublished - 27 Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Anthropometry, Birth weight, Fetal development, Fetal growth restriction, Infant growth, Leptin, Pre-eclampsia, Prenatal growth

ID: 65428511