The role of interleukin-1β in the immune response to contact allergens

Kelvin Yeung; Veronika Mraz; Carsten Geisler; Lone Skov; Charlotte M. Bonefeld

doi:10.1111/cod.13955

The role of interleukin-1β in the immune response to contact allergens

Kelvin Yeung^*, Veronika Mraz, Carsten Geisler, Lone Skov, Charlotte M. Bonefeld

^*Corresponding author for this work

Dermatology and Allergy

8 Citations (Scopus)

Abstract

Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.

Original language	English
Journal	Contact Dermatitis
Volume	85
Issue number	4
Pages (from-to)	387-397
Number of pages	11
ISSN	0105-1873
DOIs	https://doi.org/10.1111/cod.13955
Publication status	Published - Oct 2021

Keywords

allergic contact dermatitis
immunology
interleukin-1β
T cells

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10.1111/cod.13955

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title = "The role of interleukin-1β in the immune response to contact allergens",

abstract = "Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.",

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author = "Kelvin Yeung and Veronika Mraz and Carsten Geisler and Lone Skov and Bonefeld, {Charlotte M.}",

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AU - Yeung, Kelvin

AU - Mraz, Veronika

AU - Geisler, Carsten

AU - Skov, Lone

AU - Bonefeld, Charlotte M.

PY - 2021/10

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AB - Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.

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KW - T cells

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JF - Contact Dermatitis

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The role of interleukin-1β in the immune response to contact allergens

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Keywords

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