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The role of inflammation in the pathogenesis of glaucoma

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Vohra, Rupali ; Tsai, James C ; Kolko, Miriam. / The role of inflammation in the pathogenesis of glaucoma. In: Survey of Ophthalmology. 2013 ; Vol. 58, No. 4. pp. 311-20.

Bibtex

@article{a016dd54b057455baf4f78e07d408d9a,
title = "The role of inflammation in the pathogenesis of glaucoma",
abstract = "Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.",
keywords = "Animals, Anoxia, Axons, Cell Death, Glaucoma, Humans, Inflammation, Oxidative Stress, Retinal Ganglion Cells",
author = "Rupali Vohra and Tsai, {James C} and Miriam Kolko",
note = "Copyright {\circledC} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
doi = "10.1016/j.survophthal.2012.08.010",
language = "English",
volume = "58",
pages = "311--20",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier Inc",
number = "4",

}

RIS

TY - JOUR

T1 - The role of inflammation in the pathogenesis of glaucoma

AU - Vohra, Rupali

AU - Tsai, James C

AU - Kolko, Miriam

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013

Y1 - 2013

N2 - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

AB - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

KW - Animals

KW - Anoxia

KW - Axons

KW - Cell Death

KW - Glaucoma

KW - Humans

KW - Inflammation

KW - Oxidative Stress

KW - Retinal Ganglion Cells

U2 - 10.1016/j.survophthal.2012.08.010

DO - 10.1016/j.survophthal.2012.08.010

M3 - Journal article

VL - 58

SP - 311

EP - 320

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 4

ER -

ID: 42187286