The role of inflammation in the pathogenesis of glaucoma

Rupali Vohra, James C Tsai, Miriam Kolko

    168 Citations (Scopus)

    Abstract

    Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.
    Original languageEnglish
    JournalSurvey of Ophthalmology
    Volume58
    Issue number4
    Pages (from-to)311-20
    Number of pages10
    ISSN0039-6257
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Animals
    • Anoxia
    • Axons
    • Cell Death
    • Glaucoma
    • Humans
    • Inflammation
    • Oxidative Stress
    • Retinal Ganglion Cells

    Fingerprint

    Dive into the research topics of 'The role of inflammation in the pathogenesis of glaucoma'. Together they form a unique fingerprint.

    Cite this