Abstract
Regular exercise offers protection against all cause mortality and there is evidence from randomised intervention studies that physical training is effective as a treatment in patients with chronic heart diseases, type 2 diabetes and symptoms related to the metabolic syndrome. Chronic diseases such as cardiovascular disease, type 2 diabetes and cancer are associated with chronic low-grade systemic inflammation. It has been demonstrated that regular exercise induces anti-inflammatory effects with elevated levels of anti-inflammatory cytokines and suppression of TNF-alpha production. Thereby, exercise offers protection against TNF-alpha-induced insulin resistance. Otherwise, the exercise-induced production and release of IL-6 from myofibers may contribute to abrogate an atherogenic lipid profile, which is often associated with chronic diseases. This review focuses on the anti-inflammatory effects of exercise and how this may contribute to mediate the beneficial health effects of exercise training in patients with chronic diseases associated with chronic low-grade inflammation.
| Original language | English |
|---|---|
| Journal | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society |
| Volume | 57 Suppl 10 |
| Pages (from-to) | 43-51 |
| Number of pages | 9 |
| ISSN | 0867-5910 |
| Publication status | Published - Nov 2006 |
| Externally published | Yes |
Keywords
- Animals
- Chronic Disease
- Exercise/physiology
- Exercise Therapy/methods
- Humans
- Inflammation/immunology
- Interleukin-6/metabolism
- Muscle, Skeletal/metabolism
- Randomized Controlled Trials as Topic
- Tumor Necrosis Factor-alpha/metabolism