The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis-Dysregulation by the Liver

Amalie London, Anne-Marie Lundsgaard, Bente Kiens, Kirstine Nyvold Bojsen-Møller

10 Citations (Scopus)

Abstract

Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.

Original languageEnglish
Article number390
JournalJournal of Clinical Medicine
Volume10
Issue number3
Pages (from-to)1-13
Number of pages13
ISSN2077-0383
DOIs
Publication statusPublished - 20 Jan 2021

Keywords

  • glucose metabolism
  • hepatic glucose production
  • hyperinsulinemic-euglycemic clamp
  • insulin clearance
  • insulin resistance
  • molecular regulation
  • non-alcoholic fatty liver disease (NAFLD)
  • proton MR spectroscopy
  • Insulin clearance
  • Hyperinsulinemic‐euglycemic clamp
  • Hepatic glucose production
  • Proton MR spectroscopy
  • Non‐alcoholic fatty liver disease (NAFLD)
  • Molecular regulation
  • Glucose metabolism
  • Insulin resistance

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