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The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies

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  1. Counterregulatory responses to postprandial hypoglycemia after Roux-en-Y gastric bypass

    Research output: Contribution to journalJournal articlepeer-review

  2. Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss

    Research output: Contribution to journalJournal articlepeer-review

  3. Primary care physician decision making regarding referral for bariatric surgery: a national survey

    Research output: Contribution to journalJournal articlepeer-review

  4. Postprandial hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: an update

    Research output: Contribution to journalJournal articlepeer-review

  1. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

    Research output: Contribution to journalJournal articlepeer-review

  2. Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity

    Research output: Contribution to journalJournal articlepeer-review

  3. THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology

    Research output: Contribution to journalReviewpeer-review

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The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.

Original languageEnglish
JournalSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Volume17
Issue number7
Pages (from-to)1383-1391
Number of pages9
ISSN1550-7289
DOIs
Publication statusPublished - 1 Jul 2021

    Research areas

  • Exendin, Glucagon-like peptide-1, Roux-en-Y gastric bypass, Sleeve gastrectomy

ID: 64651429