Abstract
The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.
| Original language | English |
|---|---|
| Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery |
| Volume | 17 |
| Issue number | 7 |
| Pages (from-to) | 1383-1391 |
| Number of pages | 9 |
| ISSN | 1550-7289 |
| DOIs | |
| Publication status | Published - 1 Jul 2021 |
Keywords
- Exendin
- Glucagon-like peptide-1
- Roux-en-Y gastric bypass
- Sleeve gastrectomy
- Bariatric Surgery
- Gastric Bypass
- Glucagon-Like Peptide 1
- Humans
- Blood Glucose
- Gastrectomy
- Insulin
- Glucagon-Like Peptide-1 Receptor
- Diabetes Mellitus, Type 2
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